LDlink | LDscore

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at the National Cancer Institute

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Version: 7.3.0

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U.S. Department of Health and Human Services
National Institutes of Health
National Cancer Institute
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LDscore Tool

Calculate LD scores and perform LD score regression

Heritability Analysis

Genetic Correlation

LD Score Calculation

Upload pre-munged GWAS sumstats file

Special characters will be removed automatically from the file name. Use only A-Z, 0-9, dots, hyphens, and underscores.

Click here for sample format

Use example data

Scale

ObservedLiability

Population

Select...

Click here for sample format

Use example data

Scale

ObservedLiability

Population

Select...

Trait 1

Upload pre-munged GWAS sumstats file

Trait 2

Upload pre-munged GWAS sumstats file

Special characters will be removed automatically from the file name. Use only A-Z, 0-9, dots, hyphens, and underscores.

Upload *.bed, *.bim, *.fam files

(all three required and must have the same name)

Special characters will be removed automatically from the file name. Use only A-Z, 0-9, dots, hyphens, and underscores.

Click here for sample format

Use example data

Window

Machiela MJ, Chanock SJ. LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants. Bioinformatics. 2015 Jul 2.

Breeze C.E., Yao, X., Park, B., Kanigicherla, M., Lan, Q., Rothman, N., Teschendorff, A.E., Franceschini, N., Berndt, S.I., and Machiela, M.J. (2025). LDscore: a scalable, Python 3-powered web platform for LD score regression analysis. bioRxiv. 2025 Dec 19.